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First time in Odisha: Kidney Transplantation from a Deceased Pediatric Donor to an Adult as an en-bloc dual kidney transplant

On 4th March, 2024

A Tale of Hope and Life

In a remarkable tale of medical innovation and human generosity, a 1-year 9-month-old deceased pediatric donor’s kidneys were successfully transplanted en bloc into a 45-year-old woman suffering from end-stage renal disease (ESRD). This complex and delicate procedure, performed on a patient who had been dependent on dialysis for three years, highlights the transformative power of organ donation and the advances in transplant surgery that make such miracles possible.

Dr. Samiran Das Adhikary and his Team.

The Deceased Pediatric Donor: A Tragic Loss and a Legacy of Life

The deceased pediatric donor, a young child of just 1 year and 9 months, was tragically diagnosed with hydrocephalus, a condition characterized by the accumulation of excess cerebrospinal fluid in the brain. Despite undergoing treatment, the child did not recover, leading to a heartbreaking loss for his family. However, amid their grief, the family made the extraordinary decision to donate their child’s organs, a choice that would save and transform the lives of others.

The Recipient: A New Lease on Life

The recipient, a 45-year-old woman who had been battling ESRD for years, had exhausted all other options and was undergoing dialysis thrice weekly. With no suitable living donor available, her hopes for a life free from dialysis were fading.

The En Bloc Transplant: A Surgical Marvel

Due to the significant size difference between the deceased pediatric donor and the adult recipient, the decision was made to transplant the kidneys en bloc. This technique involves transplanting both kidneys along with the aorta and vena cava in a single unit. This approach ensures adequate blood flow and improves the viability of the organs, which are too small to be transplanted individually into an adult body.

The transplant surgery was carefully planned and executed by Dr. Samiran and his Team.

Early signs of success were promising, with the en bloc kidneys beginning to produce urine shortly after transplantation. Over the following weeks and months, the recipient’s health improved significantly, and she began to experience the profound relief of a life free from dialysis.

The Gift of Life: A Shared Legacy

While the kidney transplant marked a new beginning for the recipient, the deceased pediatric donor’s legacy extended beyond this single act of generosity. The child’s liver was also harvested and transported to a specialized transplant center, ILS Delhi, where it was used to perform a life-saving liver transplant.

Conclusion: A Celebration of Medical Progress and Human Kindness

This case exemplifies the incredible advancements in medical science and the enduring power of human kindness. The successful en bloc kidney transplant from a deceased pediatric donor to an adult recipient is a testament to the skill and dedication of the medical professionals involved, as well as the selfless generosity of the donor’s family. Their decision to donate their child’s organs, despite their unimaginable loss, has given others the gift of life and hope.

Milestones

  • 1st Deceased Pediatric Kidney Transplant in Odisha
  • 1st en-bloc Kidney Transplant in Odisha
  • 2nd Deceased Pediatric Kidney Transplant in India

This is a reference to the First Deceased Pediatric Kidney Transplant in India where the donor was 16 months old: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264203/

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World Kidney Day

World Kidney Day is celebrated on the second Thursday in the month of March every year.

Kidneys play a crucial role in maintaining our overall health by filtering waste products and excess fluids from the blood. These vital organs are responsible for regulating blood pressure, balancing electrolytes, and producing hormones that help control red blood cell production and bone health.

Unfortunately, kidney disease is a prevalent health concern worldwide. It can be caused by a range of factors, including high blood pressure, diabetes, genetic predisposition, and certain medications. Symptoms of kidney disease may not be apparent until the disease has progressed, making it important to take steps to maintain kidney health throughout life.

To keep your kidneys healthy, it is essential to maintain a healthy lifestyle. Eating a balanced diet, exercising regularly, staying hydrated, and avoiding smoking and excessive alcohol consumption are all important steps you can take. Additionally, managing underlying health conditions, such as high blood pressure and diabetes, can help prevent kidney damage.

If you have a family history of kidney disease or have other risk factors, it’s important to get regular kidney function tests. Early detection and treatment of kidney disease can help slow the progression of the disease and prevent complications.

In summary, taking steps to maintain kidney health is crucial for overall health and well-being. By making lifestyle changes and getting regular check-ups, you can help keep your kidneys functioning properly and reduce your risk of kidney disease.

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Repair of large Pseudo aneurysm of left upper arm AVF in a post-renal transplant patient. By Dr Samiran Adhikary. Senior Consultant in the Department of Urology Apollo hospital Bhubaneswar

This was the acute presentation with a history of pain for 3 days 

This is a 20-year-old girl. She underwent a renal transplant when she was in standard 9 by me at apollo hospital Bhubaneswar. Now she has presented to us with a history of fever and acute pain and increased swelling in her upper arm. At av fistula site. With skin color change. On imaging, it showed. Impending rupture. Which is a life-threatening problem. As it is extremely difficult to control bleeding and a person can lose a lot of blood.

The cephalic vein just proximal to the fistula is normal in caliber for a length of approximately 6 cm with the patent flow.
Large partially thrombosed pseudoaneurysm approximately 6 cm from on the fistula site measuring approximately 5.5 x 4.1 cm. Surrounding soft tissue edema and mild fluid collection is likely suggestive of leaking Pseudoaneurysm.
A short segment of normal caliber cephalic vein team (approximately 3 cm) just proximal to the pseudoaneurysm.
Significant ectasia/ Pseudo aneurysm of the proximal cephalic vein over a length of approximately 11.2 cm with a maximum width of 4.8 cm.

Repaired brachial artery
Excised in Toto 

The brachial artery was Repaired and excised the aneurysm part and unhealthy skin overlying it 

Thanks to my Team at apollo hospital Bhubaneswar. 

Dr Prateek Sahoo. Dr Ram. Mr Ashok and Mr Soumya. 

Dr Mami Parija. Anesthesia 

Dr. Ajit Biswal. Radiologist for providing a very accurate delineation of the pseudo aneurysm

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Circumcision: Conventional / LASER / ZSR which technique. Big confusion ??

Many techniques has been described. Of late I find my patients are very much confused and always come with good “ In Depth” knowledge after googling for few hours. It has become extremely difficult when a person comes to me with pre formed knowledge of certain things.

I used to get disappointed with these patients and some people even argue and try their point of view to driven in to surgeons mind and some surgeons also started doing as per the patient demand . I have stopped doing these procedures. And request them to see some other surgeons.

But now patients are coming back to me after the surgery done by someone else and their choice surgery with many complications specifically after ZSR ( Stapler ) and LASER technique and that to done by many online promotions of health and medical aggregator. I wish good luck to all my fellow surgeons and also the Uberisation of medical facilities .

Today we had to do one young gentleman who had planned his circumcision well before his marriage he had circumcision by ZSR technique elsewhere and even after two months he has a non healing ulcer in the central part with induration of tissue. He also had some repair under local by primary surgeon. Look like some foreign body inside

We had to excise all the dirty tissue and redo that part.

I have seen many patients also after LASER the issue of non healing. Where as properly done conventional circumcision heal within a weeks time as penile skin is very vascular and healing is very fast.

Healing of procedure completely depends on the vascularity of the cut edge. While the newer techniques are compromised in vascularity. So I apprehend these non healing issues and it’s long term functional outcome.

After the repair.
After excision of the unhealthy tissue.

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1st time in India we used kidney from 5 years old male as deceased donor. ( Brain Dead Donor ) and used as single kidney unit in two adults respectively

Salute to the brave parents of Master Sudhanshu Lenka who came forward to donate the organ to save two more lives. Master Sudhanshu one 5 years old boy was admitted to KIMS Hospital Bhubaneswar under the care of Pediatric Department for some convulsion related issue and after all attempts it was diagnosed and confirmed that he has become brain dead and nothing could be done to reverse it.

He was declared brain dead on 13/07/2022 evening by the team of doctors from KIMS

Our state organ transplant organization SOTTO was informed and then they alerted all stake holders concerned for the Cadaveric transplant program and co ordinated to the whole process .

Organs were harvested in KIMS and After the harvesting it was taken to SCB medical college. unfortunately no patients were found suitable for renal transplantation. So it was decided by SCB and SOTTO to send it to Apollo Hospital.

Though there was some delay we took the challenge to proceed with the transplantation and successfully did two patients one after another.

As the kidney sizes were good more then 9 Cm we decided to use for two patients as single kidney unit. Both the patients are recovering well. Both the patients were done in Apollo Hospital bhubaneswar Odisha. We did some literature review and found that single kidney transplantation vs paired kidney transplantation and they were found to be successful even in adult patients with good results at 2 years and 5 years and results were comparable So we decided to do 1st case as single unit on right then waited for some time and found to have good urine output. The size of kidney after implantation was good and was having good turgidity. As it looked satisfactory we went ahead with second patient

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801801/

https://pubmed.ncbi.nlm.nih.gov/9358086/

I thank my team .

Our team consisted of Dr Samiran Adhikary supported by Dr Prateek Sahoo, Dr Ramkumar ,Dr Sunil and Dr Saroj and Anesthetist Dr Saumitra , Dr Debabrata Dash and Dr Samarjit Bisoyi. Dr N K Mohanty Nephrologist.

I also thank Dr Alok Srvastava and Team Apollo In Apollo Hospital Bhubaneswar

I will like to have special mention about Mr Subrat SOTTO co ordinator and Mr Ayush our Transplant Co-Ordinator for their dedication and tireless endeavors

It is the 1st Pediatric deceased donor of the state of Odisha. To my knowledge I am not aware any such donor in India except one in Ahmedabad in 2009.

We are the 1st to attempt to put into adult as single kidney unit and saved two lives successfully

It is first of it kind in India as we have used as single kidney unit.

We have discharged one patient after one week of transplant with creatinine of 1.6 mg % and second one on 11th day creatinine which has reached less then 2 mg %.

After two months.
Bench dissection for the graft